Cancers, Vol. 10, Pages 211: Immunosenescence and Immunotherapy in Elderly Acute Myeloid Leukemia Patients: Time for a Biology-Driven Approach

Cancers, Vol. 10, Pages 211: Immunosenescence and Immunotherapy in Elderly Acute Myeloid Leukemia Patients: Time for a Biology-Driven Approach Cancers doi: 10.3390/cancers10070211 Authors: Alessandro Isidori Federica Loscocco Marilena Ciciarello Giulia Corradi Mariangela Lecciso Darina Ocadlikova Sarah Parisi Valentina Salvestrini Sergio Amadori Giuseppe Visani Antonio Curti Acute myeloid leukemia (AML) is a disease, which mainly affects the elderly population. Unfortunately, the prognosis of patients aged >65 years is dismal, with 1-year overall survival approaching 10% with conventional therapies. The hypothesis of harnessing the immune system against cancer, including leukemia, has been postulated for a long time, and several clinical attempts have been made in this field. In the last years, we increased our knowledge about the interplay between AML and immune cells, but no major improvement has been translated, up to now, from bench to bedside. However, the outstanding results coming from the modern immuno-oncology trials with new drugs have granted a new interest for immunotherapy in AML. Accordingly, the elderly population represents an ideal target, given the low percentage of patients eligible for allogeneic stem cell transplant. With that in mind, in the era of immunotherapy, we consider immunosenescence as the optimal background to start investigating a biology-driven approach to AML therapy in the elderly. By taking into accou...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research