Communication Between the Microbiota and Mammalian Immunity.

Communication Between the Microbiota and Mammalian Immunity.
Annu Rev Microbiol. 2018 Jun 21;:
Authors: Ost KS, Round JL
Abstract
Mammalian immune systems evolved within a diverse world dominated by microbes, making interactions between these two life-forms inevitable. Adaptive immunity protects against microbes through antigen-specific responses. In classical studies, these responses were investigated in the context of pathogenicity; however, we now know that they have significant effects on our resident microbes. In turn, microbes employ an arsenal of mechanisms to influence development and specificity of host immunity. Understanding these complex reactions will be necessary to develop microbiota-based strategies to prevent or treat disease. Here we review the literature detailing the cross talk between resident microbes with a focus on the specificity of the host response and the microbial molecules that influence them. Expected final online publication date for the Annual Review of Microbiology Volume 72 is September 8, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
PMID: 29927706 [PubMed - as supplied by publisher]

Source: Annual Review of Microbiology - June 21, 2018 Category: Microbiology Authors: Ost KS, Round JL Tags: Annu Rev Microbiol Source Type: research