Hypothesis Kynurenic and quinolinic acids: the main players of the kynurenine pathway and opponents in inflammatory disease

I hypothesize that the intermediates of the kynurenine (Kyn) pathway (KP) of tryptophan degradation kynurenic acid (KA) and quinolinic acid (QA) play opposite roles in inflammatory diseases, with KA being antiinflammatory and QA being immunosuppressant. Darlington et al. have demonstrated a decrease in the ratio of plasma 3-hydroxyanthranilic acid to anthranilic acid ([3-HAA]/[AA]) in many inflammatory conditions and proposed that this decrease either reflects inflammatory disease or is an antiinflammatory response.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research