Toxic Tau: The TAU gene polymorphisms associate with concussion history in rugby union players

Concussion is a brain injury that occurs when biomechanical forces are transmitted to the head region resulting in neurological deficits. The accumulation of tau protein in autopsies of athletes with multiple concussions implicates tau in concussion-associated neurodegeneration. The TAU rs2435211 (C> T) and rs2435200 (G> A) polymorphisms are involved in pathological tau expression and neurodegenerative disease risk. The aims of this study were to investigate the associations of TAU (rs2435211, rs2435200) polymorphisms with concussion history and sustaining multiple concussions in rugby.
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Authors: Tags: Original research Source Type: research