Strong Improvement of Apolipoprotein E/Low-Density Lipoprotein Receptor Signals by Telmisartan in Poststroke Spontaneously Hypertensive Stroke Resistant

Conclusions: These findings suggest that both low and high doses of telmisartan prevented the activation of ApoE/LDL-R in SHR-SR after tMCAO, and that the antimetabolic effect was regarded as the most important mechanism with few additional benefits by lowering BP in this transient stroke model.

http://www.strokejournal.org/article/S1052-3057(14)00196-7/abstract?rss=yes

Source: Journal of Stroke and Cerebrovascular Diseases - September 1, 2014 Category: Neurology Authors: Toru Yamashita, Yun Zhai, Tomoko Kurata, Nozomi Hishikawa, Nobutoshi Morimoto, Yasuyuki Ohta, Kentaro Deguchi, Koji Abe Tags: Original Articles Source Type: research