Otoprotectant Guards Against Cisplatin-Induced Hearing Loss Otoprotectant Guards Against Cisplatin-Induced Hearing Loss
Administration of a known otoprotectant following completion of cisplatin therapy reduces the incidence and severity of hearing loss associated with use of cisplatin in children treated for hepatoblastoma.Medscape Medical News
The epithelial cell adhesion molecule (EpCAM) is involved in oncogenesis of hepatoblastomas (HBs). Prior genomic profiling studies showed higher EpCAM expression and worse prognosis in HBs containing primitive histotypes, however, this has not been fully addressed from an immunohistochemical perspective. Our goal is to characterize differential EpCAM immunohistochemistry (EpCAM-IHC) among HBs histotypes. We retrieved 62 HBs from 52 patients. EpCAM-IHC was performed (anti-MOC-31, 1:50 dilution; Cell Marque Corporation, Rocklin, CA) and graded in histotypes using the immunoreactive score. The median age of patients was 2 yea...
Hepatocellular malignant neoplasms, not otherwise specified (NOS) display histologic features of both hepatoblastoma (HPB) and hepatocellular carcinoma and may be associated with worse outcomes. We compared demographics, tumors characteristics, surgical management, and outcomes in patients with HBP vs those with NOS.
Despite recent advances, the prognosis for advanced stage hepatoblastoma remains poor, resulting in a desperate need for novel therapies. We have previously shown that Proviral Integration site for Moloney murine leukemia virus (PIM) kinases act as oncoproteins to promote cell survival in hepatoblastoma. In addition, PIM kinases promote the hepatoblastoma cancer stem cell phenotype, which may contribute to chemoresistance. We hypothesized that a novel PIM inhibitor, PIM447, would decrease oncogenicity and cancer cell stemness in a human hepatoblastoma, patient-derived xenograft (PDX) model.
Undifferentiated embryonal sarcoma of the liver (UESL) comprises approximately 10% of all pediatric liver malignancy after hepatoblastoma and hepatocellular carcinoma. We aimed to investigate the clinicopathologic characteristics and outcomes of pediatric UESL in the US during a contemporary era.
Children with recurrent hepatoblastoma have a poor prognosis and limited treatment options. The authors describe a child with metastatic hepatoblastoma who had multiple relapses. He was treated with surgical resection and adjuvant chemotherapy at first relapse. At second relapse, he had progressive disease postresection. He was treated with ifosfamide/carboplatin/etoposide chemotherapy followed by maintenance irinotecan and achieved long-term disease-free survival. Irinotecan as maintenance should be explored in recurrent hepatoblastoma.
Conclusions: Microstructure 3 D reconstruction is feasible for observing the pathological structure of the HB tumor margin. PMID: 32969743 [PubMed - as supplied by publisher]
CONCLUSIONS: SRFA is an effective minimal-invasive treatment option in pediatric patients with liver tumors of different etiologies. PMID: 32954876 [PubMed - in process]
Conclusion Extracapsular tumor extension was a significant prognostic factor of local recurrence after surgical resection of HB. R1 margin does not necessarily require a second resection, and it could achieve accepted results when combined with adjuvant platinum-based chemotherapy. However, patients who are not eligible for surgical resection must be transferred for primary transplantation to obtain favorable outcome. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
s Sanford Simon Hepatoblastoma is the most common childhood liver cancer. Although survival has improved significantly over the past few decades, there remains a group of children with aggressive disease who do not respond to current treatment regimens. There is a critical need for novel models to study aggressive hepatoblastoma as research to find new treatments is hampered by the small number of laboratory models of the disease. Organoids have emerged as robust models for many diseases, including cancer. We have generated and characterized a novel organoid model of aggressive hepatoblastoma directly from freshly re...
k D Abstract 1,2-unsaturated pyrrolizidine alkaloids (PAs) are natural plant constituents comprising more than 600 different structures. A major source of human exposure is thought to be cross-contamination of food, feed and phytomedicines with PA plants. In humans, laboratory and farm animals, certain PAs exert pronounced liver toxicity and can induce malignant liver tumors in rodents. Here, we investigated the cytotoxicity and genotoxicity of eleven PAs belonging to different structural classes. Although all PAs were negative in the fluctuation Ames test in Salmonella, they were cytotoxic and induced micronuclei...