Histopathologic and molecular comparative analyses of intravesical Aurora kinase-A inhibitor Alisertib with bacillus Calmette –Guérin on precancerous lesions of bladder in a rat model

ConclusionsAlthough intravesical ALS treatment has similar antiproliferative effects like BCG, ALS  + BCG combined treatment led to a best histopathologic and apoptotic response. Consequently, BCG combined with Aurora-A inhibition may provide a new intravesical treatment modality in the prevention of bladder carcinogenesis.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research