Youthful systemic milieu alleviates renal ischemia-reperfusion injury in elderly mice

The incidence of acute kidney injury (AKI) is high in elderly people, and is difficult to prevent and treat. One of its major causes is renal ischemia-reperfusion injury (IRI). A young systemic environment may prevent the senescence of old organs. However, it is unknown whether a young milieu may reduce renal IRI in the elderly. To examine this question, bilateral renal IRI was induced in old (24 months) mice three weeks after parabiosis model establishment. At 24 hours after IRI, compared to old wild-type mice, the old mice with IRI had significantly damaged renal histology, decreased renal function, increased oxidative stress, inflammation, and apoptosis.

Source: Kidney International - June 20, 2018 Category: Urology & Nephrology Authors: Dong Liu, Lide Lun, Qi Huang, Yichun Ning, Ying Zhang, Linna Wang, Zhiwei Yin, Yinping Zhang, Lihua Xia, Zhong Yin, Bo Fu, Guangyan Cai, Xuefeng Sun, Xiangmei Chen Tags: Basic Research Source Type: research