P-321Profile of neurotoxicity of oxaliplatin in young versus elderly patients treated for colorectal carcinoma

Introduction: Peripheral neuropathy secondary to oxaliplatin is very frequent, these neuropathies are characterized by the symmetry of the neurological disorders and their distal predominance. In most patients, this neuropathy is only partially reversible and can persist long after the stop of chemotherapy. This is one of the major dose-limiting side effects of chemotherapy that may lead not only to the loss of function physical activity associated with a decrease in the quality of life and difficulties in daily activities, especially if it is an elderly person but which can also result in the reduction and or delay of the administration dose or even in the worst Of the cases the stop of the treatment.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research