Endometrial CRH and implantation: from bench to bedside.

Endometrial CRH and implantation: from bench to bedside. Hormones (Athens). 2018 Jun 18;: Authors: Makrigiannakis A, Vrekoussis T, Zoumakis E, Hatzidakis V, Vlachou E, Salakos N, Kalantaridou SN Abstract Endometrial corticotropin-releasing hormone (CRH) has been described as a mediator of decidualisation and as a contributor of maternal-fetal immunotolerance. Deregulation of the CRH expression pattern has been associated with unfavourable reproductive outcomes as well as chronic endometrium-derived inflammatory disorders, such as endometriosis and adenomyosis. The current review summarises the evidence produced regarding the role of CRH in endometrial physiology and pathophysiology and highlights recent clinical data regarding the role of CRH in improving clinical pregnancy rates in women with repeated implantation failures following in vitro fertilisation and embryo transfer. PMID: 29916119 [PubMed - as supplied by publisher]
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research