Maternal polycystic ovarian syndrome and early offspring development

AbstractSTUDY QUESTIONIs maternal polycystic ovarian syndrome (PCOS) associated with developmental delays in offspring?SUMMARY ANSWEROffspring of mothers with PCOS were at higher risk of failure on the Ages and Stages Questionnaire (ASQ).WHAT IS KNOWN ALREADYThere is growing evidence that offspring of mothers with PCOS may be at higher risk for developmental disorders due to potential exposure to hyperandrogenism and insulin resistance. Few studies exist regarding maternal PCOS and early childhood development in the USA.STUDY DESIGN, SIZE, DURATIONThe Upstate KIDS Study is a population-based prospective cohort study of infants born between 2008 and 2010 in New York State (excluding New York City), originally designed to study —and finding no impact of—infertility treatment exposure on child development. Children were followed up to 36 months of age. In all, 4453 mothers completed one or more developmental screening instruments for 5388 children (35.5% twins) up to 36 months of age.PARTICIPANTS/MATERIALS, SETTING, METHODSIn our study, 458 mothers (10.3%) reported a healthcare provider ’s diagnosis of PCOS, as well as the related treatment received, on the baseline study questionnaire. Parents completed the ASQ on their child’s development at 4, 8, 12, 18, 24, 30 and 36 months of age to assess fine motor, gross motor, communication, personal–social functioning and problem-so lving cognitive domains. We used generalized linear mixed models to estimate odds ratios (OR) ...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research