ICSI does not increase the cumulative live birth rate in non-male factor infertility

AbstractSTUDY QUESTIONWhat is the cumulative live birth rate following ICSI cycles compared with IVF cycles for couples with non-male factor infertility?SUMMARY ANSWERICSI resulted in a similar cumulative live birth rate compared with IVF for couples with non-male factor infertility.WHAT IS KNOWN ALREADYThe ICSI procedure was developed for couples with male factor infertility. There has been an increased use of ICSI regardless of the cause of infertility. Cycle-based statistics show that there is no difference in pregnancy rates between ICSI and IVF in couples with non-male factor infertility. However, evidence indicates that ICSI is associated with an increased risk of adverse perinatal outcomes.STUDY DESIGN, SIZE, DURATIONA population-based cohort of 14 693 women, who had their first ever stimulated cycle with fertilization performed for at least one oocyte by either IVF or ICSI between July 2009 and June 2014 in Victoria, Australia was evaluated retrospectively. The pregnancy and birth outcomes following IVF or ICSI were recorded for the first oocyte retrieval (fresh stimulated cycle and associated thaw cycles) until 30 June 2016, or until a live birth was achieved, or until all embryos from the first oocyte retrieval had been used.PARTICIPANTS/MATERIALS, SETTING, METHODSDemographic, treatment characteristics and resulting outcome data were obtained from the Victorian Assisted Reproductive Treatment Authority. Data items in the VARTA dataset were collected from all fertili...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research