The EBV-DNA Can be Used as a Diagnostic and Follow-up Parameter of the Rhinopharyngeal Tumors in the Non-Endemic Population of the Western Sicily

AbstractTo evaluate whether EBV-DNA can be used as a diagnostic and follow-up parameter for nasopharyngeal tumors in a non-endemic population. The study was carried out in a university hospital. A retrospective study was conducted on 40 paraffin samples of histological preparations. EB-DNA was detected by real-time PCR technique. A prospective study was also conducted on a group of 30 patients who underwent nasopharyngeal biopsy for suspected nasopharyngeal carcinoma (NPC) by comparing EBV-DNA concentrations between the histological specimen and the serum. Quantification of genomic copies of EBV-DNA in serum and detection of anti-EBV antibodies was performed. In both groups the presence of high viral load of EBV-DNA was found in nonkeratinizing squamous cell carcinomas, in three cases of lymphepitomyoma and in 4 out of 6 cases of non-differentiated non-carcinoma lymph node metastases. squamous keratinizing cells. In all cases of NPC, an antibody pattern typical of reactivations (IgGVCA+, IgG-EA+, IgG-EBNA+) and IgA-EA-D, frequently positive in cases of NPC, has been highlighted. A good correlation between the high EBV-DNA charges and the histological diagnosis was highlighted. Our study also found that the assessment of viral EBV load can also be considered in the prognostic evaluation and in the follow-up of patients with NPC.
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research

Related Links:

CONCLUSIONS In the transferred patients with a malignant cytology, preoperative US might be helpful to detect false-positive cytology cases. PMID: 31522188 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: AlHussain H, Balbaid A, Malyapa R, AlOthman M, Bahadur YA, Tunio MA, Al Asiri M Abstract The Saudi Particle Therapy Centre (SPTC) is establishing proton beam therapy (PBT) services within Kingdom of Saudi Arabia (KSA). Thus, national guidelines for the pertinent draft, and recommendations of PBT for cancer patients are utmost important. Saudi Particle Therapy Centre invited a panel of expert radiation oncologists practicing within KSA to formulate national clinical practice guidelines for the referral, absolute and relative indications and dose/fractionation for PBT. After identifying the key clinical...
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
BACKGROUND: Self-report measures of sensation seeking though commonly used in research have not undergone factor structure or psychometric validation in Indian adolescents. The Brief Sensation Seeking Scale - Chinese (BSSS-C; Chen et al., 2013) is a less c...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
The present study compared selective attention processing among juvenile delinquents of two different citizenships and matched control groups. The sample consisted of 70 "true" juvenile delinquents (Indian citizen--charged for theft, rape or murder), 54 "l...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Publication date: Available online 16 September 2019Source: The American Journal of SurgeryAuthor(s): Minyoung Kwak, J. Hunter Mehaffey, Robert B. Hawkins, Angel Hsu, Bruce Schirmer, Peter T. HallowellAbstractIntroductionObesity is a risk factor for non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Bariatric surgery can provide durable weight-loss, but little is known about the later development of NASH and HCC after surgery.MethodsBariatric surgery (n=3,410) and obese controls (n=46,873) from an institutional data repository were propensity score matched 1:1 by demographics, comorbidities, BMI, and ...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Condition:   Metastatic Renal Cell Carcinoma Interventions:   Drug: Ipilimumab;   Radiation: SBRT Sponsors:   Ontario Clinical Oncology Group (OCOG);   Bristol-Myers Squibb Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   Advanced Breast Carcinoma;   Anatomic Stage III Breast Cancer AJCC v8;   Anatomic Stage IIIA Breast Cancer AJCC v8;   Anatomic Stage IIIB Breast Cancer AJCC v8;   Anatomic Stage IIIC Breast Cancer AJCC v8;   Anatomic Stage IV Breast Cancer AJCC v8;   Germlin e BRCA1 Gene Mutation;   Germline BRCA2 Gene Mutation;   HER2/Neu Negative;   Metastatic Breast Carcin...
Source: - Category: Research Source Type: clinical trials
We report two female patients diagnosed as poorly differentiated squamous cell carcinoma, subsequently, their further histological examinations showed that tumor cells were EBER positive and plasma EBV DNA was detectable.Diagnoses:Two patients was diagnosed with advanced pulmonary LELC.Interventions:The patients were treated with chemotherapy and chemoradiotherapy respectively.Outcomes:Both patients responded well to our treatment, in accordance with their decreased EBV DNA level.Lessons:Pulmonary LELC is a rare type of lung cancer which is sensitive to chemoradiotherapy, especially in late staged patients. Rationale: ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
This article is protected by copyright. All rights reserved.
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
Human papillomavirus and Epstein-Barr virus in nasopharyngeal carcinoma in a non-endemic eastern european population. Neoplasma. 2015 Dec 7; Authors: Svajdler M, Kaspirkova J, Mezencev R, Laco J, Torday T, Dubinsky P, Straka L, Ondic O, Michal M, Skalova A Abstract Nasopharyngeal carcinoma (NPC) is a rare malignancy in the Czech Republic and Slovakia, with the standardized incidence rate of
Source: Neoplasma - Category: Cancer & Oncology Authors: Tags: Neoplasma Source Type: research
More News: Cancer & Oncology | Carcinoma | Endemics | ENT & OMF | Hospitals | India Health | Nasopharyngeal Cancer | Squamous Cell Carcinoma | Study