The role of cancer-associated fibroblast MRC-5 in pancreatic cancer

Conclusion: MRC-5 limits the malignant activities of PC cells by suppressing cancer stem cell expansion, remolding epithelial polarity, and blocking the protumoral cascade reaction coupled to TLR4, TLR1, CD14, and CD25.

Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Song-Ming Ding, Ai-Li Lu, Wu Zhang, Lin Zhou, Hai-Yang Xie, Shu-Sen Zheng, Qi-Yong Li Tags: Research Paper Source Type: research