SULT1E1 inhibits cell proliferation and invasion by activating PPAR γ in breast cancer

In this study, we explored the functional and molecular mechanisms by which SULT1E1 influenced breast cancer. Here, we identified that overexpression of SULT1E1 inhibited breast cancer cell growth through inducing apoptosis and arresting cell cycle progression. Furthermore, enforced expression of SULT1E1 suppressed tumor cell migration and invasion. Moreover, we found that the activation of PPARγ was required for SULT1E1-mediated downregulation of C-myc, Cyclin D1, MMP-2 and MMP-9 as well as for cell apoptosis, migration and invasion. In addition, the overexpression of SULT1E1 significantly inhibited tumor growth in vivo. Taken together, our findings indicated that SULT1E1 performed its tumor suppressor characteristics by activating PPARγ, which provided a novel target for patients with breast cancer.

Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yali Xu, Xiaoyan Lin, Jiawen Xu, Haiyan Jing, Yejun Qin, Yintao Li Tags: Research Paper Source Type: research