LncRNA MALAT1 negatively regulates MDSCs in patients with lung cancer

In this study, we observed an increased proportion of MDSCs and elevated levels of the related molecule arginase-1 (ARG-1) in peripheral blood mononuclear cells (PBMCs) obtained from lung cancer patients. The proportion of CD8+ cytotoxic T lymphocyte (CTL) was significantly decreased in PBMCs from lung cancer patients. Moreover, the proportion of CTL cells was negatively correlated with the proportion of MDSCs. Furthermore, MALAT1 levels were decreased in PBMCs from lung cancer patients. The relative expression of MALAT1 was moderate negatively correlated with the proportion of MDSCs. In vitro results indicate that the knockdown of MALAT1 significantly increased the proportion of MDSCs. Our data provide the first evidence that lncRNA MALAT1 negatively regulates MDSCs and is decreased in PBMCs from lung cancer patients.

Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Qinfeng Zhou, Xinyi Tang, Xinyu Tian, Jie Tian, Yue Zhang, Jie Ma, Huaxi Xu, Shengjun Wang Tags: Research Paper Source Type: research