Maternal and infant outcomes associated with lithium use in pregnancy: an international collaborative meta-analysis of six cohort studies

Publication date: Available online 18 June 2018 Source:The Lancet Psychiatry Author(s): Trine Munk-Olsen, Xiaoqin Liu, Alexander Viktorin, Hilary K Brown, Arianna Di Florio, Brian M D'Onofrio, Tara Gomes, Louise M Howard, Hind Khalifeh, Holly Krohn, Henrik Larsson, Paul Lichtenstein, Clare L Taylor, Inge Van Kamp, Richard Wesseloo, Samantha Meltzer-Brody, Simone N Vigod, Veerle Bergink Background Concerns about teratogenicity and maternal and offspring complications restrict the use of lithium during pregnancy for the treatment of mood disorders. We aimed to investigate the association between in-utero lithium exposure and risk of pregnancy complications, delivery outcomes, neonatal morbidity, and congenital malformations. Methods In this meta-analysis, primary data from pregnant women and their children from six international cohorts based in the community (Denmark, Sweden, and Ontario, Canada) and in clinics (the Netherlands, UK, and USA) were analysed. Pregnancies were eligible for analysis if the pregnancy resulted in a liveborn singleton between 1997 and 2015, if health-related information was available for both mother and infant, and if the mother had a mood disorder (bipolar disorder or major depressive disorder) or if she had been given lithium during pregnancy (at least two dispensations of lithium during pregnancy that were dispensed any time from 1 month before conception until the delivery, or a single lithium dispensation during pregnancy whe...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research