PrLZ increases prostate cancer docetaxel resistance by inhibiting LKB1/AMPK-mediated autophagy

Conclusion: These findings identify a novel role of PrLZ in autophagy manipulation and provide new insight into docetaxel chemoresistance in PCa, suggesting a new strategy for treating mCRPC by targeting this newly identified signaling pathway.

Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Jin Zeng, Wei Liu, Yi-Zeng Fan, Da-Lin He, Lei Li Tags: Research Paper Source Type: research