MiR-31-5p-ACOX1 Axis Enhances Tumorigenic Fitness in Oral Squamous Cell Carcinoma Via the Promigratory Prostaglandin E2

Conclusions: Collectively, our findings outlined a model whereby misregulated miR-31-5p-ACOX1 axis in tumor alters lipid metabolomes, consequently eliciting an intracellular signaling change to enhance cell motility. Our clinical analysis also unveiled PGE2 as a viable salivary biomarker for prognosticating oral cancer progression, further underscoring the importance of lipid metabolism in tumorigenesis.

Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Yi-Hsuan Lai, Hsuan Liu, Wei-Fan Chiang, Ting-Wen Chen, Lichieh Julie Chu, Jau-Song Yu, Shu-Jen Chen, Hua-Chien Chen, Bertrand Chin-Ming Tan Tags: Research Paper Source Type: research