Targeted Delivery of Functionalized Upconversion Nanoparticles for Externally Triggered Photothermal/Photodynamic Therapies of Brain Glioblastoma

Conclusion: In vitro and in vivo data strongly indicate that the ANG-IMNPs were capable of selectively delivering dual photosensitizers to brain astrocytoma tumors for effective PDT/PTT in conjugation with a substantially improved median survival. The therapeutic efficacy of ANG-IMNPs demonstrated in this study suggests their potential in overcoming BBB and establishing an effective treatment against GBM.

Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Yuan-Chung Tsai, Priya Vijayaraghavan, Wen-Hsuan Chiang, Hsin-Hung Chen, Te-I Liu, Ming-Yin Shen, Ayumu Omoto, Masao Kamimura, Kohei Soga, Hsin-Cheng Chiu Tags: Research Paper Source Type: research