Phosphorylation of IRS4 by CK1 γ 2 promotes its degradation by CHIP through the ubiquitin/lysosome pathway

Conclusions: IRS4, as a new substrate of CHIP, is negatively regulated by CK1γ2 at the posttranslational level, and specific CK1γ2 agonists may be a potentially effective strategy for treating patients with osteosarcoma.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research