Glomerular permeability changes of albumin in isolated glomeruli do not mimic changes in albumin excretion in vivo in diseased states
The study by Desideri et al.1 investigates the changes in albumin permeability in isolated glomeruli treated by enzymatic removal of the endothelial glycocalyx, or treatment with plasma from human steroid-resistant nephrotic syndrome or in glomeruli from rats treated with streptozotocin for 4 weeks. In all cases these cha nges in albumin glomerular permeability were small (by a factor
Source: Kidney International - Category: Urology & Nephrology Authors: Wayne D. Comper Tags: Letter to the Editor Source Type: research