Glomerular permeability changes of albumin in isolated glomeruli do not mimic changes in albumin excretion in  vivo in diseased states

The study by Desideri et  al.1 investigates the changes in albumin permeability in isolated glomeruli treated by enzymatic removal of the endothelial glycocalyx, or treatment with plasma from human steroid-resistant nephrotic syndrome or in glomeruli from rats treated with streptozotocin for 4 weeks. In all cases these cha nges in albumin glomerular permeability were small (by a factor 
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research