Dysfunctional bone marrow mesenchymal stem cells in patients with poor graft function after allogeneic hematopoietic stem cell transplantation
Poor graft function (PGF), characterized by pancytopenia, is a severe complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) [1 –3]. However, the exact pathogenesis of PGF remains unclear, and effective treatment options for PGF are limited [1–4]. Murine studies demonstrated that effective hematopoiesis in the bone marrow (BM) depends on the interaction between hematopoietic stem cells (HSCs) and specific BM microenviron ment [5–8]. Therefore, in previous studies, we focused on the quantity and function of HSCs and BM microenvironment elements in PGF patients [9–14].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Yang Song, Hong-Yan Zhao, Zhong-Shi Lyu, Xie-Na Cao, Min-Min Shi, Qi- Wen, Fei-Fei Tang, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Yuan Kong Source Type: research