Dysfunctional bone marrow mesenchymal stem cells in patients with poor graft function after allogeneic hematopoietic stem cell transplantation

Poor graft function (PGF), characterized by pancytopenia, is a severe complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) [1 –3]. However, the exact pathogenesis of PGF remains unclear, and effective treatment options for PGF are limited [1–4]. Murine studies demonstrated that effective hematopoiesis in the bone marrow (BM) depends on the interaction between hematopoietic stem cells (HSCs) and specific BM microenviron ment [5–8]. Therefore, in previous studies, we focused on the quantity and function of HSCs and BM microenvironment elements in PGF patients [9–14].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research