Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4 [Original Articles]

Conclusions: Basal cardiac pacemaker function is regulated by concurrent PDE3+PDE4 activation which operates in a synergistic manner via decrease in cAMP/PKA phosphorylation, suppression of LCR parameters, and prolongation of the LCR period and spontaneous SANC cycle length.

http://circep.ahajournals.org/cgi/content/short/11/6/e005896?rss=1

Source: Circulation: Arrhythmia and Electrophysiology - June 7, 2018 Category: Cardiology Authors: Vinogradova, T. M., Sirenko, S., Lukyanenko, Y. O., Yang, D., Tarasov, K. V., Lyashkov, A. E., Varghese, N. J., Li, Y., Chakir, K., Ziman, B., Lakatta, E. G. Tags: Calcium Cycling/Excitation-Contraction Coupling, Cell Signaling/Signal Transduction, Ion Channels/Membrane Transport Original Articles Source Type: research

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