Interaction of Localized Drivers and Disorganized Activation in Persistent Atrial Fibrillation: Reconciling Putative Mechanisms Using Multiple Mapping Techniques [Original Articles]

Conclusions:
Sites at which persistent AF terminated by ablation show organized activation that fluctuate over time, because of collision from concurrent organized zones or fibrillatory waves, yet recur in conserved spatial regions. Results were similar by 2 mapping methods. This network of competing mechanisms should be reconciled with existing disorganized or driver mechanisms for AF, to improve clinical mapping and ablation of persistent AF.

Clinical Trial Registration:
URL: http://www.clinicaltrials.gov. Unique identifier: NCT02997254.

Source: Circulation: Arrhythmia and Electrophysiology - June 8, 2018 Category: Cardiology Authors: Kowalewski, C. A. B., Shenasa, F., Rodrigo, M., Clopton, P., Meckler, G., Alhusseini, M. I., Swerdlow, M. A., Joshi, V., Hossainy, S., Zaman, J. A. B., Baykaner, T., Rogers, A. J., Brachmann, J., Miller, J. M., Krummen, D. E., Sauer, W. H., Peters, N. S., Tags: Electrophysiology, Atrial Fibrillation, Computational Biology, Mechanisms Original Articles Source Type: research