Transient Outward K+ Current (Ito) Underlies the Right Ventricular Initiation of Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long-QT Syndrome Type 1 [Original Articles]

Conclusions:
Ito heterogeneity creates both triggers and an arrhythmogenic substrate in LQT1. In the absence of IKs, Ito interactions with ICa,L and IKr promote EADs in the RV while prolonging action potential duration in the left ventricle. This heterogeneity of action potential enhances dispersion of refractoriness and facilitates conduction blocks that initiate pVTs.

Source: Circulation: Arrhythmia and Electrophysiology - May 16, 2018 Category: Cardiology Authors: Choi, B.-R., Li, W., Terentyev, D., Kabakov, A. Y., Zhong, M., Rees, C. M., Terentyeva, R., Kim, T. Y., Qu, Z., Peng, X., Karma, A., Koren, G. Tags: Arrhythmias, Electrophysiology, Basic Science Research, Mechanisms Original Articles Source Type: research