Pharmacokinetics variability: Why nanoparticles are not just magic-bullets in oncology

Developing nanoparticles to improve the specificity of anticancer agents towards tumor tissue and to better control drug delivery is a rising strategy in oncology. An increasing number of forms (e.g., conjugated nanoparticles, liposomes, immunoliposomes …) are now available on the shelves and numerous other scaffolds (e.g., dendrimeres, nanospheres, squalenes …) are currently at various stages of development. However, as of today most nanoparticles made available remain lipidic carriers. Pharmacokinetic variability is a major, yet largely under estimated issue with liposomal nanoparticles.
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research