Supplemental Carbon Dioxide Stabilizes the Upper Airway in Volunteers Anesthetized with Propofol

We present a prespecified, secondary analysis of previously published experiments in 12 volunteers breathingvia a high-flow respiratory circuit used to control upper airway pressure under propofol anesthesia at two levels, with the deep level titrated to suppression of motor response. Ventilation, mask pressure, negative pharyngeal pressure, upper airway closing pressure, genioglossus electromyogram, bispectral index, and change in end-expiratory lung volume were measured as a function of elevation of Petco2 above baseline and depth of propofol anesthesia.Results Petco2 augmentation dose-dependently lowered upper airway closing pressure with a decrease of 3.1  cm H2O (95% CI, 2.2 to 3.9;P
Source: Anesthesiology - Category: Anesthesiology Source Type: research

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ConclusionCatastrophizing was associated with acute pain intensity, and lower pain-related catastrophizing among patients with acute herpes zoster was associated with less risk of PHN development, independent of acute pain intensity.
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research
The α2-adrenergic receptor agonist dexmedetomidine has sedative, anxiolytic, analgesic, and sympatholytic effects. The potential advantages of neuroprotection, minimal impact on neuronal function, stable hemodynamics, opioid and anesthesia sparing effects, and minimal respiratory depression during awake procedures render it an effective anesthetic adjuvant in various neurosurgical settings. However, both the benefits and drawbacks of the use dexmedetomidine in neuroanesthesia should be considered. This narrative review will summarize the applications of dexmedetomidine in various neurosurgical settings, highlighting ...
Source: Journal of Neurosurgical Anesthesiology - Category: Anesthesiology Tags: Review Articles Source Type: research
Abstract Rapid stabilization of patients with acute aggression and agitation using either pharmacological or physical restraint is frequently needed to prevent injury of patients, bystanders and providers.1 Pharmacological restraint need to have quick onset of action, be easily administered, and be safe for patients.1 Benzodiazepines and antipsychotics such as haloperidol are probably the most often used medication to control acutely agitated patients.1 However, these drugs have slow onsets of action (in 15 to 30 min) when given intramuscularly, and have significant adverse events including respiratory failure, ca...
Source: Pain Physician - Category: Anesthesiology Authors: Tags: Book Source Type: research
CONCLUSION For nulliparous women with single-term cephalic pregnancy planning for vaginal delivery, the use of neuraxial analgesia during labour was associated with a reduced risk of maternal depression at 2 years after childbirth. TRIAL REGISTRATION www.chictr.org.cn: ChiCTR-OCH-14004888 and ClinicalTrials.gov: NCT02823418.
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Obstetric anaesthesia Source Type: research
This study aimed to analyze whether exposure to environmental enrichment (EE) during the juvenile phase of life interferes with the electrical activity of the adult rat brain. In addition, the present research also investigated whether this putative effect on brain electrical activity could be affected by prior overnutrition during lactation. Electrophysiology was measured through cortical spreading depression (CSD), a phenomenon related to brain excitability. Methods: Wistar rats were suckled in litters of either nine or three pups, forming the nourished (N) or overnourished (ON) groups, respectively. At 36 days old, half...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
Conclusion: Regular survey of patients' satisfaction should help to improve the quality of medical care. The strong excitement of the patient about the upcoming anesthesia and surgery, and the presence of a high level of anxiety and depression can be factors of reducing the patients' satisfaction with anesthesia. It requires psychological support of patients at the stage of surgical treatment.
Source: Saudi Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research
Conclusion: ADHD Rats were not sensitive to postoperative neurocognitive disorder (PND). Surgery with general anesthesia could partly improve the hyperactivity symptom of ADHD rats. This mechanism was related to the suppression of neural activity in cerebral NAc of ADHD rats induced by general anesthetics.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
ConclusionRepeated intake of caffeine aggravates PTSD-like symptoms in stress-exposed rats and induces PTSD-like symptoms in unstressed rats by altering the expression of glucocorticoid receptors.Graphical abstract
Source: Physiology and Behavior - Category: Physiology Source Type: research
Propofol is routinely used by oral and maxillofacial surgeons for outpatient procedures with the known complication of respiratory depression. The purpose of this study is to find a safe alternative for outpatient procedures requiring anesthesia, such as third molar removal, by comparing the use of 2 anesthetic medication combinations: midazolam/fentanyl/propofol (group P) versus midazolam/dexmedetomidine (group D).
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
(Anesth Analg. 2019;128:513–522) Neuraxial morphine in low dosages is commonly used to provide high-quality analgesia to women after cesarean delivery. However, postoperative respiratory depression remains a concern, with reported incidences ranging from 0 to 32%. Inadequacy of ventilation and apneas can reliably be detected via capnography but current monitoring relies predominantly on pulse oximetry. No study has evaluated capnography use in women after cesarean delivery. Therefore, in the present study, the authors used capnography to estimate the number of “apnea alert events” (AAEs) in women who und...
Source: Obstetric Anesthesia Digest - Category: Anesthesiology Tags: Editor’s Picks Source Type: research
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