Noninvasive Tracking of Anesthesia Neurotoxicity in the Developing Rodent Brain

Conclusions Our data demonstrate the feasibility of using the biomarker N-acetyl-aspartate, measured noninvasively using proton magnetic resonance spectroscopy, for longitudinally monitoring anesthesia-induced neurotoxicity. These results also indicate that the neonatal rodent brain is more vulnerable to multiple anesthesia exposures than to a single exposure of the same cumulative duration.
Source: Anesthesiology - Category: Anesthesiology Source Type: research