γ-Aminobutyric Acid Type A Receptor Potentiation Inhibits Learning in a Computational Network Model

Conclusions Memory formation is widely thought to depend on changes in neuronal connection strengths during learning that enable neuronal groups to respond with greater facility to familiar stimuli. This experiment suggests the ability to form such groups is sensitive to alteration in the balance between excitation and inhibition such as that resulting from administration of a γ-aminobutyric acid–mediated anesthetic agent.
Source: Anesthesiology - Category: Anesthesiology Source Type: research