Cryptic exon splicing function of tardbp interacts with autophagy in nervous tissue.

In conclusion, the present findings demonstrate abnormal alternative splicing of ATG4B transcripts in ALS neural tissue in agreement with TARDBP loss of function, leading to impaired autophagy.
PMID: 29912613 [PubMed - as supplied by publisher]

Source: Autophagy - June 18, 2018 Category: Cytology Authors: Torres P, Ramírez-Núñez O, Romero-Guevara R, Barés G, Granado-Serrano AB, Ayala V, Boada J, Fontdevila L, Povedano M, Sanchís D, Pamplona R, Ferrer I, Portero-Otín M Tags: Autophagy Source Type: research