Synthesis of modified proteins via functionalization of dehydroalanine.

Synthesis of modified proteins via functionalization of dehydroalanine. Curr Opin Chem Biol. 2018 Jun 15;46:71-81 Authors: Dadová J, Galan SR, Davis BG Abstract Dehydroalanine has emerged in recent years as a non-proteinogenic residue with strong chemical utility in proteins for the study of biology. In this review we cover the several methods now available for its flexible and site-selective incorporation via a variety of complementary chemical and biological techniques and examine its reactivity, allowing both creation of modified protein side-chains through a variety of bond-forming methods (C-S, C-N, C-Se, C-C) and as an activity-based probe in its own right. We illustrate its utility with selected examples of biological and technological discovery and application. PMID: 29913421 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research