Iron overload involved in the enhancement of unloading-induced bone loss by hypomagnetic field

During deep-space exploration missions, astronauts will be exposed to abnormal space environments including microgravity and hypomagnetic field (HyMF) that is 10,000 times weaker than geomagnetic field (GMF). It is well known that microgravity in space can induce bone loss; however, it is ill-defined whether HyMF involved in this process. Herein, we aimed to investigate the combined effects of HyMF and microgravity on bone loss. A mouse model of hindlimb suspension (HLU) was adopted to simulate microgravity-induced bone loss, that was exposed to a hypomagnetic field of

Source: Bone - June 18, 2018 Category: Orthopaedics Authors: Jiancheng Yang, Xiaofeng Meng, Dandan Dong, Yanru Xue, Xin Chen, Shenghang Wang, Ying Shen, Gejing Zhang, Peng Shang Tags: Full Length Article Source Type: research