Combined Tricuspid, Mitral Valve Repair Linked to Better Outcomes

(MedPage Today) -- But tricuspid repair may not be necessary after TAVR
Source: MedPage Today Cardiovascular - Category: Cardiology Source Type: news

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CONCLUSIONS: In this cadaver study, when using cannulated screws and a figure-of-eight tension band to fix transverse patella fractures, prominent screws reduced the construct's ability to resist gap formation during cyclic loading testing. CLINICAL RELEVANCE: This biomechanical cadaver study found that the use of prominent cannulated screws for the fixation of transverse patella fractures increases the likelihood of interfragmentary gap formation, which may potentially increase the risk of fracture nonunion and implant failure. These findings suggest that proximally and distally recessed screws may increase construct...
Source: Clinical Orthopaedics and Related Research - Category: Orthopaedics Authors: Tags: Clin Orthop Relat Res Source Type: research
Abstract BACKGROUND: Few studies have examined long-term outcomes for patients after arthroscopic treatment for intraarticular hip conditions, and none have done so beyond 10 years postarthroscopy. Examining outcomes beyond 10 years is necessary to determine factors that contribute to conversion to THA in patients undergoing hip arthroscopy for labrochondral damage. QUESTIONS/PURPOSES: (1) What is hip survivorship free from THA in patients who underwent arthroscopic labral débridement, with or without chondroplasty at least 15 years before? (2) What factors are associated with conversion to THA after a...
Source: Clinical Orthopaedics and Related Research - Category: Orthopaedics Authors: Tags: Clin Orthop Relat Res Source Type: research
Conclusion: The laparoendoscopic technique of hiatal hernia repair, using extracorporeal arthroscopic sliding knots and concomitant transoral incisionless fundoplication, is safe, preserves an ALHA, and allows proper surgical techniques in a confined operative field. PMID: 30996584 [PubMed - in process]
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - Category: Surgery Tags: JSLS Source Type: research
We present a case of diagnosed xeroderma pigmentosum in a 25 year old male who presented with multiple lesions and non-healing ulcers on face. Four surgical specimens from left lower eyelid, chin, right cheek and upper lip were taken for histopathological diagnosis. Microscopic examination revealed five different tumors from biopsies of these sites - specimen from right cheek revealed two morphologically distinct tumors. The tumors include basosquamous carcinoma, nodular basal cell carcinoma, adenoid basal cell carcinoma, malignant melanoma and cavernous hemangioma. PMID: 30992739 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Alpha beta ( αβ) T cells in adult skin play a critical role in defense against infections and malignancy while also promoting homeostatic functions such as wound repair. Comparatively little is known about the phenotype and function of these cells during human skin development. Here we performed flow cytometry on fetal skin ranging from 17 to 23 weeks gestational age (GA) in order to interrogate the early dynamics of αβ T cell accumulation in human skin and elucidate phenotypic differences between these fetal populations and their adult counterparts.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by skin and ocular abnormalities with increased risk of melanoma and non-melanoma skin cancer. XP patients with defects in the nucleotide excision repair pathway genes (XP A-G) are hypersensitive to ultraviolet radiation from sunlight. We recently diagnosed an XP-C patient with mixed phenotype acute leukemia, a rare type of leukemia. Using whole exome and whole genome sequencing we identified more than 150 somatic mutations in the blast cells from the patient.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research
Background: Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder of DNA repair. XP patients are highly sun-sensitive with 10,000-fold increased risk of skin cancer. XP is caused by mutations in 8 genes, XP-A to -G, and Variant. XP-C is the most common in the U.S. About 12% of XP-C patients have premature termination codon (PTC) mutations that can lead to XPC protein elongation arrest and XPC mRNA template degradation by nonsense mediated decay. Our studies have shown that aminoglycosides increased XPC mRNA and XPC protein expression levels in fibroblasts derived from XP-C patients with PTC mutations.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research
Genome editing represents a promising strategy to correct COL7A1 gene mutations that cause recessive dystrophic epidermolysis bullosa (RDEB). Previously, we used programmable nucleases that create double-stranded DNA breaks (DSBs) to repair COL7A1 mutations through homology-directed repair (HDR) with an exogenous repair template. Delivery of this template can be cytotoxic and DSBs induce undesired insertions and deletions (indels) that compete with desired HDR. To overcome these limitations, we used base editors (BE), a CRISPR/Cas9-based system that uses naturally occurring or laboratory-evolved deaminating enzymes to dire...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research
Skin protects our body against the outer environment, and its ability to repair upon injury is directly connected to both disease and survival. Despite recent advances in our understanding of skin homeostasis, it is still unclear how diverse cell types interact with each other to sustain this process. The critical barrier to addressing these fundamental questions lies in the inability to simultaneously follow behaviors of different cell types and to define their functional interactions in a live mammal.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidermal Structure and Barrier Function Source Type: research
Cellular senescence is an irreversible state of cell cycle arrest that is induced during cellular aging. In the skin, senescence is associated with phenotypic changes in cutaneous structure and cells, lowered resistance to oxidative stress and DNA damage, decreased epidermal cell renewal, decreased synthesis of extracellular matrix protein and the appearance of markers of aging (senescence-associated beta-galactosidase, etc.). Many genes have been reported to be involved in the regulation of senescence: senescence genes, senescence suppressors, oncogenes, tumor suppressors, stemness genes, inflammation-related genes, genes...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidermal Structure and Barrier Function Source Type: research
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