Postural tachycardia syndrome (PoTS): An up-to-date.

[Postural tachycardia syndrome (PoTS): An up-to-date]. Rev Med Interne. 2018 Jun 13;: Authors: Astudillo L, Laure A, Fabry V, Pugnet G, Maury P, Labrunée M, Sailler L, Pavy-Le Traon A Abstract Postural tachycardia syndrome (PoTS) is a multifactorial syndrome defined by an increase in heart rate ≥30bpm, within 10minutes of standing (or during a head up tilt test to at least 60°), in absence of orthostatic hypotension. It is associated with symptoms of cerebral hypoperfusion that are worse when upright and improve in supine position. Patients have an intense fatigue with a high incidence on quality of life. This syndrome can be explained by many pathophysiological mechanisms. It can be associated with Ehlers-Danlos disease and some autoimmune disorders. The treatment is based on nonpharmacological measures and treatment with propranolol, fludrocortisone or midodrine. PMID: 29909001 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research

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This study aims to validate this observation. Blood levels of seven cytokines were measured in 120 patients with pSS from the United Kingdom Primary Sjögren’s Syndrome Registry and 30 age-matched healthy non-fatigued controls. Patient-reported scores for fatigue were classified acco rding to severity and compared to cytokine levels using analysis of variance. The differences between cytokines in cases and controls were evaluated using Wilcoxon test. A logistic regression model was used to determine the most important identifiers of fatigue. Five cytokines, interferon-γ-induced protein-10 (IP-10), tumour ne...
Source: Rheumatology International - Category: Rheumatology Source Type: research
AbstractWe read with great interest the letter of Xieet al commenting on our article “Safety and Efficacy of Immune Checkpoint Inhibitors in Patients with Cancer and Preexisting Autoimmune Disease: A Nationwide Multicenter Cohort Study”(1).First, the authors suggested classifying Preexisting Autoimmune Diseases (PAD) according to systems, in order to assess if rheumatic disorders were more likely to flare with ICI. Such trend has been reported in other series, like Menzieset al and Leonardiet al, with the limit that the majority of the PAD in their cohort was a rheumatic disorder (n=27, 52% and n=25 (45%) respectively) (2,3).
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: REPLY TO LETTER TO THE EDITOR Source Type: research
AbstractWe read with great interest the article by Tison et al profiling safety and efficacy of immune checkpoint inhibitors (ICIs) in individuals with cancer and preexisting autoimmune disease (PAD) (1). In this nationwide multicenter cohort study including largest population after Kehl KL's report (2), the occurrence of the PAD flare/other immune related adverse events (irAE) was frequent but mostly manageable without ICIs discontinuation. However, some issues should be addressed. Firstly, previous studies based on relatively small sample size indicated there are differences of flare rate among PAD of different systems (...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: LETTER TO THE EDITOR Source Type: research
ConclusionOur study showed a significant association between alterations in intestinal microbial composition and T1D; however, in some articles, it is not clear which one happens first. Investigation of altered gut microbiota can help in the early detection of T1D before seropositivity. Targeted microbiome modulation can be a novel potential therapeutic strategy.
Source: Gut Pathogens - Category: Microbiology Source Type: research
Conclusions/interpretationOur study identifies a proinsulin-derived peptide region that is highly diabetogenic on the HLA-DR3-DQ2 background using an in vivo model. This approach and the peptide region identified may have wider implications for future studies of human type 1 diabetes.
Source: Diabetologia - Category: Endocrinology Source Type: research
This report demonstrates the variable cardiac rhythm in two species of subterranean mole, the large Japanese mole (Mogera wogura) and the lesser Japanese mole (Mogera imaizumii). The phenomenon was revealed using X-ray videos ofM. wogura and investigated in detail using electrocardiogram (ECG) traces recorded with implanted electrodes in this species andM. imaizumii. Cessation of heartbeat and extendedR–R intervals were observed in the ECGs from both species during short bouts of rest in wakeful specimens of both species under normoxic conditions at room temperature. The mean durations ofR–R intervals were 288....
Source: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology - Category: Physiology Source Type: research
by Alireza Tafazzol, Yong Duan Toll-like receptors (TLRs) play a central role in both the innate and adaptive immune systems by recognizing pathogen-associated molecular patterns and inducing the release of the effector molecules of the immune system. The dysregulation of the TLR system may cause various autoimmune diseases and septic shock. A series of molecular dynamics simulations and free energy calculations were performed to investigate the ligand-free, lipopolysaccharide (LPS)-bound, and neoseptin3-bound (TLR4-MD2)2 tetramers. Compared to earlier simulations done by others, our simulations showed that TLR4 structure...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
Publication date: Available online 9 October 2019Source: NeuroImageAuthor(s): Aline M. Thomas, Jiadi Xu, Peter A. Calabresi, Peter C.M. van Zijl, Jeff W.M. BulteAbstractMultiple sclerosis (MS) is an autoimmune disorder that targets myelin proteins and results in extensive damage in the central nervous system in the form of focal lesions as well as diffuse molecular changes. Lesions are currently detected using T1-weighted, T2-weighted, and gadolinium-enhanced magnetic resonance imaging (MRI); however, monitoring such lesions has been shown to be a poor predictor of disease progression. Chemical exchange saturation transfer...
Source: NeuroImage - Category: Neuroscience Source Type: research
In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health. Deletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice https://www.fightaging.org/archives/2019/10/deletion-of-p38%ce%b1-in-neurons-slows-neural-stem-cell-decline-and-loss-of-cognitive-function-in-mice/ Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
There is a saying that being poor is expensive. From personal experience, I know this to be true. But I think it also needs to be said that, especially in the United States, chronic illness can be quite expensive as well. In fact, there is a huge intersection between poverty and disability/illness. As with many intersections, it is a chicken-or-egg scenario, difficult to determine which is begetting which. But one thing is clear: there are often blind spots about these expenses in the medical community and how they can impact chronically ill people already struggling with finances. Recently I attended a seminar on the topi...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Health care Health policy Pain Management Source Type: blogs
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