Three new pentacyclic triterpenoids from twigs of Manniophyton fulvum (Euphorbiaceae)

Publication date: October 2018 Source:Phytochemistry Letters, Volume 27 Author(s): Ahri Bernie Djamen Mbeunkeu, Anatole Guy Blaise Azebaze, Michel Feussi Tala, Jean Emmanuel Mbosso Teinkela, Xavier Siwe Noundou, Rui Werner Maçedo Krause, Juliette Catherine Vardamides, Hartmut Laatsch Phytochemical investigation of the methanol extracts of the twigs of Manniophyton fulvum has led to the isolation and characterization of three new pentacyclic triterpenoids, designated as 3α,28-dihydroxyfriedelan-1-one (1), manniotaraxerol A (3) and manniotaraxerol B (4), along with fourteen known compounds, 3α-hydroxy-1-oxofriedelane (2), betulinic acid (5), friedelin (S1), taraxerol (S2), a mixture of stigmasterol (S3) and β-sitosterol (S4), herranone (S5), docosanoic acid (S6), ursolic acid (S7), nasutin B (S8), bergenin (S9), stigmasterol-3-O-β-d-glucopyranoside (S10), 1,2-di-O-palmitoyl-3-O-(6-sulfo-α-d-quinovopyranosyl)glycerol (S11), and aridanin (S12). The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR, EI and ESI-MS). 3α,28-Dihydroxyfriedelan-1-one (1), 3α-hydroxy-1-oxofriedelane (2), manniotaraxerol A (3), manniotaraxerol B (4), and betulinic acid (5) were evaluated against HeLa (human cervix adenocarcinoma) cancer cells. Manniotaraxerol A (3) showed weak in vitro cytotoxicity with a cell viability value of 49.3%. Betulinic acid (5) also showed significant cytotoxicity against HeLa cell with a cell viability value of...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research