Global Health: Nearly Eradicated in Humans, the Guinea Worm Finds New Victims: Dogs

For 30 years, scientists have fought to eliminate a horrifying parasite. Suddenly, it has begun infecting dogs in Chad, threatening to undo decades of progress.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Guinea Worm Disease Dogs Frogs Parasites Epidemics Carter Center Carter, Jimmy Deby, Idriss Chad Africa Source Type: news

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Publication date: April 2020Source: Parasitology International, Volume 75Author(s): Hideyuki Iriko, Tomoko Ishino, Mayumi Tachibana, Ayaka Omoda, Motomi Torii, Takafumi TsuboiAbstractPlasmodium falciparum proteins involved in vascular endothelial cell adherence are transported to the surface of infected erythrocytes. These proteins are exported through parasite-derived membrane structures within the erythrocyte cytoplasm called Maurer's clefts. Skeleton binding protein 1 (SBP1) is localized in the Maurer's clefts and plays an important role in transporting molecules to the surface of infected erythrocytes. Details of the t...
Source: Parasitology International - Category: Parasitology Source Type: research
Publication date: Available online 12 November 2019Source: Veterinary ParasitologyAuthor(s): Pornanan Kueakhai, Kulathida Chaithirayanon, Athit Chaiwichien, Tepparit Samrit, Supawadee Osotprasit, Phawiya Suksomboon, Wipaphorn Jaikua, Prasert Sobhon, Narin ChangklungmoaAbstractGlutathione peroxidases (GPx), major antioxidant enzymes, secreted by Fasciola spp., are important for the parasite evasion and protection against the host’s immune responses. In the present study, a monoclonal antibody (MoAb) against recombinant F. gigantica glutathione peroxidase (rFgGPx) was produced by hybridoma technique using spleen cells ...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Publication date: Available online 12 November 2019Source: MicronAuthor(s): Andrezza Raposo Borges de Melo, Taciana Mirely Maciel Higino, Aline Dulce Pitt da Rocha Oliveira, Adriana Fontes, Diego César Nunes da Silva, Maria Carolina Accioly Brelaz de Castro, José Arimatéia Dantas Lopes, Regina Celia Bressan Queiroz de FigueiredoAbstractChagas disease, caused by the protozoan Trypanosoma cruzi, is considered a public health problem. The current chemotherapy for this illness causes serious side effects and its use in the chronic phase of the disease is still controversial. In this sense, the investigatio...
Source: Micron - Category: Biology Source Type: research
Publication date: Available online 13 November 2019Source: Journal of Theoretical BiologyAuthor(s): Robert J. Hardwick, Carolin Vegvari, James E. Truscott, Roy M. AndersonAbstractBuilding on past research, we here develop an analytic framework for describing the dynamics of the transmission of soil-transmitted helminth (STH) parasitic infections near the transmission breakpoint and equilibria of endemic infection and disease extinction, while allowing for perturbations in the infectious reservoir of the parasite within a defined location. This perturbation provides a model for the effect of infected human movement between ...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
AbstractChagas disease or American trypanosomiasis is a major public health problem in Latin America. Approximately seven million people are currently infected worldwide. Despite the efforts to develop new drugs, only two nitroheterocyclic drugs (nifurtimox and benznidazole) are available for the treatment of Chagas disease, These drugs have been available since the 1970s, and no new drugs have been approved. Due to the lack of alternatives for the treatment of this disease, this review describes recent advances (2013 –2019) concerning nitroheterocyclic compounds with activity againstT. cruzi parasites, as well as ne...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
This study is registered with ClinicalTrials.gov, NCT02193776, and all patients have completed follow-up.FindingsBetween Oct 24, 2014, and Dec 15, 2015, we enrolled 180 patients with drug-susceptible tuberculosis (59 were randomly assigned to BloadPaZ, 60 to B200PaZ, and 61 to HRZE) and 60 patients with rifampicin-resistant tuberculosis. 57 patients in the BloadPaZ group, 56 in the B200PaZ group, and 59 in the HRZE group were included in the primary analysis. B200PaZ produced the highest daily percentage change in TTP (5·17% [95% Bayesian credibility interval 4·61–5·77]), followed by BloadPaZ (4&...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Publication date: Available online 13 November 2019Source: Current Medicine Research and PracticeAuthor(s): Parijat Chandra, Dr. Rajendra Prasad
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
The objective of the present st...
Source: Journal of Medicinal Plants Research - Category: Complementary Medicine Source Type: research
Current challenges: from the path of "original antigenic sin" towards the development of universal flu vaccines. Int Rev Immunol. 2019 Nov 09;:1-16 Authors: Biswas A, Chakrabarti AK, Dutta S Abstract Annual flu led by influenza viruses is contemplated to be one of the foremost global health challenges due to its rapid spread leading to the life-threatening epidemic or pandemic. An enormous number of people die due to flu and its associated intricacies every year. Annual vaccination is considered to be the gold standard strategy to protect the individual from acquiring infection and further de...
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
Publication date: Available online 11 November 2019Source: Spatial and Spatio-temporal EpidemiologyAuthor(s): Yusuf Ransome, S.V. Subramanian, Dustin T. Duncan, Daivid Vlahov, Joshua WarrenAbstractDrug- and alcohol-poisoning deaths remain current public health problems. Studies to date have typically focused on individual-level predictors of drug overdose deaths, and there remains a limited understanding of the spatiotemporal patterns and predictors of the joint outcomes. We use a hierarchical Bayesian spatiotemporal multivariate Poisson regression model on data from (N=167) ZIP-codes between 2009 and 2014 in New York City...
Source: Spatial and Spatio-temporal Epidemiology - Category: Epidemiology Source Type: research
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