Better implants key to repair damaged knees

(Stellenbosch University) People whose knees have been affected by osteoarthritis, also known as the 'wear and tear' arthritis, often have to get knee implants to repair the damage. But if a knee implant does not fit the specific individual, it could lead to soft tissue damage, collapsing of the underlying bone, loosening of the implant and an increased likelihood of joint pain after an operation. One possible solution is to design implants that are patient-specific, anatomically accurate, reproduce normal knee motion and are ultimately repeatable.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Publication date: July 2018Source: Pharmacology &Therapeutics, Volume 187Author(s): Angela Wang, Daniel J. Leong, Luis Cardoso, Hui B. SunAbstractArthritis is a chronic disease of joints. It is highly prevalent, particularly in the elderly, and is commonly associated with pain that interferes with quality of life. Because of its chronic nature, pharmacological approaches to pain relief and joint repair must be safe for long term use, a quality many current therapies lack. Nutraceuticals refer to compounds or materials that can function as nutrition and exert a potential therapeutic effect, including the relief of pain,...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impa...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Most of us will have felt the temporary effects of a disrupted body clock, whether it’s caused by a long flight, a changing shift pattern or even just a few late nights. Butscientists all over the world now recognise the importance of our biological clocks to lifelong health and well-being.In 2014 Arthritis Research UK invested more than a million pounds into two five-year studies at the University of Manchester investigating how disruption to our daily circadian rhythms is linked to osteoarthritis and inflammatory arthritis. In this edition we’re reporting on how this exciting new research is building our unde...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news
Most of us will have felt the temporary effects of a disrupted body clock, whether it’s caused by a long flight, a changing shift pattern or even just a few late nights. Butscientists all over the world now recognise the importance of our biological clocks to lifelong health and well-being.In 2014 Arthritis Research UK invested more than a million pounds into two five-year studies at the University of Manchester investigating how disruption to our daily circadian rhythms is linked to osteoarthritis and inflammatory arthritis. In this edition we’re reporting on how this exciting new research is building our unde...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news
Arthritis Research UK has announced new funding for three of its flagship research centres. Since launching in 2012, the centres, which specialise in adolescent rheumatology and osteoarthritis, have already laid the foundation for clinical advances. The new funding will run for five years and will help the researchers continue to explore how arthritis develops and potential ways to treat and prevent the condition.Arthritis Research UK supports exceptional research that aims to prevent the onset of arthritis, develop a cure for arthritis and transform the lives people living with the condition. As part of this, the charity ...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news
Publication date: Available online 24 February 2018 Source:Pharmacology & Therapeutics Author(s): Angela Wang, Daniel J. Leong, Luis Cardoso, Hui B. Sun Arthritis is a chronic disease of joints. It is highly prevalent, particularly in the elderly, and is commonly associated with pain that interferes with quality of life. Because of its chronic nature, pharmacological approaches to pain relief and joint repair must be safe for long term use, a quality many current therapies lack. Nutraceuticals refer to compounds or materials that can function as nutrition and exert a potential therapeutic effect, including the relief ...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Patients with a certain form ofarthritis have a new preventative treatment option available to them, following the recent NHS approval of a cutting-edge cartilage cell transplantation procedure. Autologous chondrocyte implantation (ACI) has won approval to be funded across the NHS thanks to a growing body of clinical evidence - supported by Arthritis Research UK and others - that has conclusively demonstrated the considerable benefits the technique offers. How the procedure works ACI is designed to help patients who have small areas of cartilage damage or earlyosteoarthritis of the knee. These conditions can often affect y...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news
Abstract Ageing processes play a major contributing role for the development of Osteoarthritis (OA). This prototypic degenerative condition of ageing is the most common form of arthritis and is accompanied by a general decline, chronic pain and mobility deficits. The disease is primarily characterized by articular cartilage degradation, followed by subchondral bone thickening, osteophyte formation, synovial inflammation and joint degeneration. In the early stages, osteoarthritic chondrocytes undergo phenotypic changes that increase cell proliferation and cluster formation and enhance the production of matrix-remod...
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research
The need for new and effective ways to treat and preventosteoarthritis has never been more urgent. Demand for total joint replacements is rising every year, and expected to double by 2030, placing a huge strain on the NHS. Meanwhile, those living with the pain of early stage osteoarthritis or at risk of developing it due to injury face limited treatment options.That’s why Arthritis Research UK is investing in innovative research dedicated to developing medical technologies which could provide an answer. By 'medical technologies' we mean cutting-edge medical devices, orthotics, implants and imaging techniques, harness...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news
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