Baltimore biotech WindMIL Therapeutics raises $32.5 million

Baltimore biotechnology firm WindMIL Therapeutics has raised a $32.5 million to support clinical trials and further development for new cancer therapies. The Series B round was led by QiMing USA Venture Partners, the new U.S. entity of China firm QiMing. WindMIL, a cell therapy company, is previously backed by about $11 million in funding. WindMIL was founded out of Johns Hopkins University by researchers Kimberly Noonan and Dr. Ivan Borrello. Th e clinical stage company is working to develop…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news

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Conclusions MDSC are major players in the immunosuppressive scenario in cancer, thanks to their phenotype heterogeneity and critical interaction with several innate immune cells, thus representing a crucial target in oncology. Here we reviewed the interactions of MDSCs with NK cells. The contribution of key cytokines, chemokines and mediators active in this process have been discussed. We also described the contribution of MDSC on angiogenesis directly or indirectly through interactions with NK and immunosuppressive activities. A parallel of the cancer associated to the decidual counterpart of these cells is discussed, a...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study aimed to explore the potential moderating effect of mindfulness and its facets on the relationships among perceived stress and mental health outcomes (burnout, depression, anxiety, and subjective well-being) among Chinese intensive care nurses. A total of 500 Chinese intensive care nurses completed self-report measures of mindfulness, burnout syndromes, perceived stress, depression, anxiety, and subjective well-being. Correlation and hierarchical multiple regressions were applied for data analysis. Mindfulness moderated the effects of perceived stress on emotional exhaustion (the core component of burnout syndro...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusion This first application of targeted NGS for the molecular diagnosis of NS in South Africans suggests that clinical characteristics and genotype-phenotype correlations found in affected individuals are generally similar to those reported in other populations. Therefore, careful phenotyping based on existing diagnostic criteria can effectively enable the diagnosis of most NS-affected individuals in South Africa. The use of targeted NGS in the present study have allowed for detection of novel variants in genes infrequently associated with NS in other populations. Further studies of a larger African cohort with NS, ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
This study was carried out in accordance with the recommendations of “the UAB Institutional Review Board for Human Use (IRB)” with written informed consent from all subjects. The protocol was approved by the “The UAB Institutional Review Board for Human Use (IRB).” This study was carried out in accordance with the recommendations of “UAB IACUC committee.” The protocol was approved by the “UAB IACUC.” All subjects gave written informed consent in accordance with the Declaration of Helsinki. Author Contributions SW, AvH, and BRK were involved in patient recruitment, examinati...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Publication date: Available online 15 March 2019Source: Journal of Geriatric OncologyAuthor(s): Sukeshi Patel Arora, Anne M. Noonan, Noam Vanderwalde, Grant R. Williams
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
RIT1 oncoproteins have emerged as an etiologic factor in Noonan syndrome and cancer. Despite the resemblance of RIT1 to other members of the Ras small guanosine triphosphatases (GTPases), mutations affecting RIT1 are not found in the classic hotspots but rather in a region near the switch II domain of the protein. We used an isogenic germline knock-in mouse model to study the effects of RIT1 mutation at the organismal level, which resulted in a phenotype resembling Noonan syndrome. By mass spectrometry, we detected a RIT1 interactor, leucine zipper–like transcription regulator 1 (LZTR1), that acts as an adaptor for p...
Source: ScienceNOW - Category: Science Authors: Tags: Cell Biology, Genetics reports Source Type: news
Future Oncology, Ahead of Print.
Source: Future Oncology - Category: Cancer & Oncology Authors: Source Type: research
Collective cell migration is required for normal embryonic development and contributes to various biological processes, including wound healing and cancer cell invasion. The M-Ras GTPase and its effector, the Shoc2 scaffold, are proteins mutated in the developmental RASopathy Noonan syndrome, and, here, we report that activated M-Ras recruits Shoc2 to...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
Publication date: Available online 30 December 2018Source: Cancer GeneticsAuthor(s): Jianling Ji, Fariba Navid, Mathew C. Hiemenz, Maki Kaneko, Shengmei Zhou, Sulagna Saitta, Jaclyn A. BiegelAbstractGermline pathogenic variants in CBL are associated with an autosomal dominant RASopathy and an increased risk for malignancies, particularly juvenile myelomonocytic leukemia. Herein, we describe a patient with clinical features of a Noonan-spectrum disorder who developed embryonal rhabdomyosarcoma of the bladder at age two years. Tumor analysis using the OncoKids® cancer panel revealed a CBL pathogenic variant: NM_005188.3:...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
MRAS is the closest relative to the classical RAS oncoproteins and shares most regulatory and effector interactions. However, it also has unique functions, including its ability to function as a phosphatase regulatory subunit when in complex with SHOC2 and protein phosphatase 1 (PP1). This phosphatase complex regulates a crucial step in the activation cycle of RAF kinases and provides a key coordinate input required for efficient ERK pathway activation and transformation by RAS. MRAS mutations rarely occur in cancer but deregulated expression may play a role in tumorigenesis in some settings. Activating mutations in MRAS (...
Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Tags: Ras and Cancer in the 21st Century PERSPECTIVES Source Type: research
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