ZAAPS programme results for 2016: an activity and spectrum analysis of linezolid using clinical isolates from medical centres in 42 countries

ConclusionsThese results document the continued long-termin vitro potency of linezolid. Alterations in the 23S rRNA and/or L3/L4 proteins remain the main oxazolidinone resistance mechanisms inE. faecium and CoNS, whereasoptrA emerged as the sole mechanism inE. faecalis. Surveillance and infection control will be important strategies to detectoptrA and prevent it from disseminating.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research