Efflux pump inhibitor CCCP to rescue colistin susceptibility in mcr-1 plasmid-mediated colistin-resistant strains and Gram-negative bacteria

ConclusionsThese results suggest an efflux mechanism, especially on intrinsically resistant bacteria andEnterobacter spp., but further analysis is needed to identify the molecular support of this mechanism. EPIs could be an alternative for restoring colistin activity in Gram-negative bacteria. Further work is necessary to identify new EPIs that could be used in humans.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research
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