Suicidal overdose of dolutegravir: A case report

We report a 29-year-old man with clinical stage 1 HIV infection who had been started on DTG, tenofovir and emtricitabine eight months prior, and who was admitted following a suicidal overdose of 1500 mg o f DTG. He reported only minor symptoms including vomiting, epigastric pain and dizziness; which promptly resolved following supportive treatment. On admission, full blood count, liver function tests and electrocardiography were unremarkable. However, there was a non-progressive increase in serum cre atinine. After a month off ARVs, he was successfully restarted on antiretroviral therapy without any serious adverse effect.
Source: Southern African Journal of HIV Medicine - Category: African Health Authors: Source Type: research