Synthesis, characterization, antioxidant and antimicrobial activity of novel 5-arylidene-2-ferrocenyl-1,3-thiazolidin-4-ones

Publication date: 15 August 2018 Source:Journal of Organometallic Chemistry, Volume 869 Author(s): Anka Pejović, Aleksandra Minić, Jovana Jovanović, Marko Pešić, Danijela Ilić Komatina, Ivan Damljanović, Dragana Stevanović, Vladimir Mihailović, Jelena Katanić, Goran A. Bogdanović Synthesis of twenty novel 5-arylidene-2-ferrocenyl-1,3-thiazolidin-4-ones has been achieved in good to excellent yields by the Knoevenagel condensation of 2-ferrocenyl-1,3-thiazolidin-4-ones with aromatic aldehydes. The reaction was performed by refluxing the mixture of reactants and potassium tert-butoxide in dioxane overnight. All new compounds were characterized by the IR and NMR spectral data, and their electrochemical properties were investigated using the cyclic voltammetry. The X-ray crystal structure of one of the representative thiazolidin-4(1H)-ones is also presented. All obtained products were evaluated for their in vitro antioxidant, antibacterial and antifungal activity. Graphical abstract
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research