Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management

AbstractPurpose of ReviewThe aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality.Recent FindingsRecent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies.SummaryAlthough the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI.
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research