LncRNA UCA1 sponges miR-26a to regulate the migration and proliferation of vascular smooth muscle cells.

CONCLUSION: The expression of UCA1 antagonized the effect of miR-26a on the downregulation of its target PETN and contraction phenotype. This study reveals that lncRNA UCA1 act as an endogenous sponge of miR-26a and downregulates miR-26a expression levels, and thereby relieving the inhibition of its target gene PTEN and alleviates VSMCs proliferation against atherosclerosis. PMID: 29908280 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29908280?dopt=Abstract

Source: Gene - June 13, 2018 Category: Genetics & Stem Cells Authors: Tian S, Yuan Y, Li Z, Gao M, Lu Y, Gao H Tags: Gene Source Type: research