Pharmacokinetics of Continuous Infusion Beta-Lactams in the Treatment of Acute Pulmonary Exacerbations in Adult Cystic Fibrosis Patients.

CONCLUSIONS: Clinicians should monitor BL levels along with aminoglycoside levels and make dose adjustments to maximize the chance of optimal antibiotic treatment. CI BL and tobramycin clearance can change dramatically during treatment of an APE which may necessitate significant changes in dosing in order to achieve optimal antibiotic levels. Clearance rates of these antibiotics may change in opposite directions requiring specific monitoring of each medication. PMID: 29908155 [PubMed - as supplied by publisher]
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research