Cytotoxic alkaloids from the fruits and seeds of Alangium salviifolium (L.f.) Wangerin

Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Si-Yuan Zhou, Fengkai Fan, Ji-Zheng Sun, Ziyan Guo, Wen-Ting Sun, Ling Chen, Qing-Qing Tang, Guofu Qiu, Sheng-Ping Yang, Jianqing Yu, You-Sheng Cai One new cepheline-type alkaloid 8-hydroxyl-cepheline (1) and one new natural product Δ1′,2′-deoxytubulosine (2), together with 9 known alkaloids have been isolated from the fruits and seeds of Alangium salviifolium (L.f.) Wangerin. The structures of the new alkaloids were elucidated by means of extensive spectroscopic analysis (2D NMR, HRESIMS). All alkaloids were evaluated for their cytotoxic activity against three human cancer cell lines, A-549, Hela and SKOV-3. Compounds 1-4, 6, 8 and 9 exhibited significant inhibitory effects against three human cancer cells with IC50 values (0.1–14 μM) comparable to those of cisplatin. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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