Development of tactile sensory circuits in the CNS.

Development of tactile sensory circuits in the CNS.
Curr Opin Neurobiol. 2018 Jun 13;53:66-75
Authors: Iwasato T, Erzurumlu RS
Abstract
Molecular identification of neuronal types and genetic and imaging approaches to characterize their properties reveal morphological, physiological and dynamic aspects of sensory circuit development. Here we focus on the mouse tactile sensory circuitry, with particular emphasis on the main trigeminal pathway that connects the whiskers, the major tactile organ in rodents, to the neocortex. At each level of this pathway, neurogenesis, axonal elongation, pathfinding, target recognition and circuit reorganization including dendritic refinement of cortical layer 4 neurons occur contemporaneously and a multitude of molecular signals are used in differing combinations. We highlight recent advances in development of tactile circuitry and note gaps in our understanding.
PMID: 29908482 [PubMed - as supplied by publisher]

Source: Current Opinion in Neurobiology - June 13, 2018 Category: Neurology Authors: Iwasato T, Erzurumlu RS Tags: Curr Opin Neurobiol Source Type: research