Preoperative Neuropathic Pain Like Symptoms and Central Pain Mechanisms in Knee Osteoarthritis Predicts Poor Outcome 6 Months After Total Knee Replacement Surgery

Knee osteoarthritis (OA) pain has been traditionally attributed to the activation of peripheral nociceptors within the joint or peri-articular structures 49. Significant discordance between radiographic features and knee pain severity 31 has led to researchers investigating the central pain mechanisms with the identification of OA subgroups with different pain phenotypes 2, 4 –7,39,40. Up to 34% of OA patients exhibit neuropathic pain-like symptoms 25,26,42,53 (electric shock sensations 25,26, burning pain 14 and allodynia 48) which have been associated with symptoms of central pain facilitation 24,35.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Original Reports Source Type: research