Immunomodulatory effects of human amniotic epithelial cells on naive CD4+ T cells from women with unexplained recurrent spontaneous abortion

Immune imbalance at the maternal-fetal interface plays a fundamental role in the pathogenesis of unexplained recurrent spontaneous abortion (URSA). Human amniotic epithelial cells (hAECs) possess pregnancy-friendly immunomodulatory effects. Here, we investigated how function of naive CD4+ T cells from URSA patients is affected by hAECs.

Source: Placenta - June 16, 2018 Category: Reproduction Medicine Authors: Hossein Motedayyen, Amir-Hassan Zarnani, Nader Tajik, Somayeh Ghotloo, Abbas Rezaei Source Type: research